The analysis of p16 gene deletion and p53 gene mutation in colorectal carcinoma
Liu Kunping
Zhong Ying
MO Jianfeng
Abstract：Objective To study the p16 gene deletion and p53 gene mutation, and their relationship with protein expression and clinicopathological features.Methods p16 gene deletion and p53 gene mutation were detected by SSCP-PCR, and their proteins were measured by immunohistochemical technique in 40 cases of colorectal cancer.Results The p16 gene deletion rate was 48% and no mutation was found. p16 protein expression deletion rate was 55%. p53 gene mutation ration was 30%. p53 protein expression rate was 68%. There were significant difference between grade Ⅱ，Ⅲ and grade Ⅰ in p16 gene deletion, and between dukes D and Dukes B or C in p53 gene mutation. Conclusion p16 gene deletion and p53 gene mutation may be associated with progression of colorectal carcinoma.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 485-486 )