Influence of mild hypothermic ischemic preconditioning on liver ultrastructure damage followed ischemia-reperfusion injury
Abstract：Objective To study the influence of mild hypothermic ischemic preconditioning on liver ultrastructure followed ischemia -reperfusion injury.Methods 24 dogs were randomly divided into four groups: nonischemic controls(C) group(n=6)， ischemia-reperfusion (I-R) group (n=6)，ischemic preconditioning(IP) group(n=6) and mild hypothermic ischemic preconditioning(MHIP) groups(n=6). Ultrastructual changes of liver were studied by electron microscope. Results Ultrastructural damage of the liver was more severe in I-R; Ultrastructual changes of liver was mild in both of IP and MHIP,but protective effects to mitochondria was better in MHIP than that in IP（P＜0.01, P＜0.05）. Conclusion Ischemic preconditioning has protective effects on ultrastructural damage of the liver after ischemia- reperfusion；Mild hypothermia can enhance the protective effect of IP followed hepatic ischemia -reperfusion injury.
Machine-generated Keywords：
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 476-477 )