nNOS expression and morphological study in hippocampus and cerebral cortex neuron of aged rats with cerebral ischemia
Abstract：Objective To study the role of nitric oxide synthase and neuronal ultrastructure changes in hippocampus and cerebral cortex neuron after transient cerebral ischemia in the aged rats.Methods The aged SD rat model with cerebral ischemia was set up for studying the expression of nNOS by immunohistochemistry and neuron morphology by transmission electron microscopy (TEM) at different timepoint.Results The activity of nNOS in the 12 h-reperfusing group after 30 minutes of cerebral ischemia was significantly higher than those in other groups. While the group reperfusing over 24 h had a more serious neuron damage.Conclusion NO played an important role in hippocampus and cerebral cortex damage in aged rats with cerebral ischemia.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 379-380 )