The effects of mifepristone on the cerebral ultrastructure of trimester pregnant rats
Luo Huijuan
Wang Zineng
Abstract：Objective To study the effects of mifepristone on the cerebral ultrastructure of trimester pregnant rats. Methods 10 pregnant rats were divided into an experimental group (n=5) and a control group (n=5) randomly. At the 20th day of gestation, the experimental rats were given 1ml of sesame oil and (11.5±1) mg of mifespristone, while the control rats were given sesame oil only. After labour, the cortical tissues of the right parieto-cerebrum were taken for TEM observation. Results Compared with the control group, the experimental group showed following morphological changes: ① Neuron swelled and membranous cytoplosmic organellae decreased; ② Dendrites and axons were partially damaged and major dense lines of myelin sheath were seperated; ③ Synaptic connections decreased and interstitiums swelled; ④ Neurogliocytes also swelled. Mitochonidria in capillary epithelial cells puffed and the extracellular matrixes of capillaries widened. Conclusion Mifespristone induces ischemia-hypoxia changes in cerebrums of female rats.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 376-378 )