Study on anti-ovarian antibodies and anti-zona pellucida antibodies and their classfication in auto-immune premature ovarian failure
Abstract：Objective To study the level and classfication of anti-ovarian antibodies (AoAb) and anti-zona pellucida antibodies (AZpAb) in the sera of premature ovarian failure (POF) patients and to study the pathogenesis of POF. Methods The level and classfication of AoAb and AZpAb in the sera from patient with POF, female infertility with the positive AsAb and the female patient with unexplained infertility were detected by using an enzyme-linked immunosorbent assay (ELISA). Results The level of AoAb and AZpAb in the sera from patient with POF, female infertility with the positive AsAb and female unexplaned infertile patients were significantly higher than those in normal control (P＜0.01). Classfication of antibodies demonstrated that they were major IgG in the sera of POF, positive AsAb infertile and unexplaned infertile group. IgA and IgM were less. Conclusion There are significant relation between POF and auto-immunity, important for further study and prevention of auto-immune POF.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 205-206 )