Estrogen modulate the activity of nitric oxide synthase in vascular endothelial cell
Abstract：Objective To investigate the effect of estrogen on vascular endothelial nitric oxide synthase (NOS).Methods Rat vascular endothelial cells(EC) were cultured according to the block explanting method and propagated in phenol-red free 1640 medium. The cells were treated with 10 nmol 17β-estradiol.Results Treatment with 10 nmol 17β-estradiol over 8 hours to 24 hours significantly enhanced NOS activity (E２ vs control 8 h， P＜0.05； 16 h, 24 h, P＜0.01) in EC.Conclusion 17β-estradiol enhance the activity of NOS in vascular endothelial cells, which may explain the benificial effect of estrogen in the prevention of atherosclerosis.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 199-200 )