The relationship between myelin basic protein and the prognosis of spinal cord injury
Abstract：Objective To study the relationship between myelin basic protein (MBP) in serum or cerebrospinal fluid (CSF) of the disease in patients with acute spinal cord injury and severity and prognosis.Methods Serum and CSF level of MBP were measured by ELISA in 51 patients within 24 hours after acute spinal cord injury . The severity of spinal cord injury was retropspecxtively evaluated in terms of recovery 6 months after injury. Results Mean serum and CSF concentration of MBP raised significantly within 24 h after injury in patient with complete and incomplete spinal cord injury (ASIA B or C). MBP level in incomplete spinal cord injury was lower than that in complete spinal cord injury. However patients with spinal cord concussion or incomplete spinal cord injury (ASIA D), did not have increased MBP levell. The serum concentration was parallel to that of CSF. Conclusion Measuring myelin basic protein in serum and CSF in patients with spinal cord injury is helpful for assessment of severity and prognosis.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 127-128 )