The effect of G-CSF and GM-CSF on the proliferation of myeloid leukemic cells
Abstract：Objective To analyse the effect of G-CSF (Granocyte) and GM-CSF on proliferation of myeloid leukemic cells. Methods Methylcellulose semi-solid culture assay was used to evaluate the effect of G-CSF and GM-CSF on peripheral blood colony forming units-leukemia (CFU-L) in 11 patients with AML or CML. Results The stimulatory effect of GM-CSF in CFU-L was significant higher than G-CSF（P=0.012）, and in compare with the control group the effect of proliferation of G-CSF in CFU-L was not significant (P=0.495). Conclusion The effect of G-CSF on the colony-forming capacity of myeloid leukemic cells is not significant in vitro. It may be safer to use G-CSF for supporting high-dose chemotherapy in myeloid leukemia.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 122-123 )