Relationship between apolipoprotein E gene polymorphism and hyperlipidemia
Abstract：Objective To study the influence apolipoprotein E(apoE) gene polymorphism on plasma lipid levels and hyperlipidemia. Methods By using PCR-RFLP, we determined apoE genotype of 87 hyperlipidemia patients and 163 healthy controls. Other plasma lipid para-meters were measured by routine method. Results Four genotypes of apoE, E3/3, E3/2, E4/3 and E4/2 were detected in this study. There were statistically significant differences in apoE4/3 and ε4 frequencies between CHD patients and controls (P＜0.05). Hyperlipidemia patients had higher plasma total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) than those of controls (P＜0.05). Among different apoE genotypes, there were statistically significant difference in TC and LDL-C level (ε4＞ε3＞ε2). Conclusion that apoE gene polymorphism may affect plasma lipid levels. apoE ε4 may be an important genetic factor of hyperlipidemia.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 120-121 )