Preventive effect of lipid-free soy powder on bone loss in ovariectomized rats
Zhang Tong
LI Wangen
Abstract：Objective To investigate the effect of lipid-free soy powder （SP） in preventing bone loss in ovariectomized（OVX） rats. Methods Thirty SD rats were randomly divided into three groups. In Sham group, sham-operated rats were fed with a casein-based diet; In SP group, OVX rats were with fed with a SP-based diet and in Casein group, OVX rats were fed with a casein-based diet. The experiments lasted for 8 weeks. Results ①The lumbar vertebral bone mineral density (BMD) and compressive strength in SP group were significantly lower than in Sham group (P＜0.05, P＜0.01, respectively). The femoral BMD and bending strength showed no difference between the two groups. BMD and strength of both bones were both significantly higher in SP group than in Casein group (P＜0.05 for BMD and P＜0.01 for strength of both bones). ②The uterine weight of rats in both SP group and Casein group were significantly lower than in Sham group (P＜0.05 for both). Conclusion SP can entirely prevent bone loss of the femour and can partially prevent bone loss of lumbar vertebra in OVX rats without uterotrophic activity.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 118-119 )