Prevention of bacterial translocation by glutamine in trats with obstructive jaundice
Abstract：Objective To study the influence of glutamine on bacterial translocation of rats with obstructive jaundice (OJ). Methods 90 rats were divided randomly into three groups (control, OJ and Glutamine group)(n=30), OJ model was induced by obstruction of common bile duct. Rats in glutamine group were fed with glutamine once daily. The histology and DNA content of intestine mucosa and the number of E.Coli labeled with acridine orange in mesentery lymph node (MLN) were observered. Results There were obvious lesions in the intestinal mucosa and significant decrease in DNA content in mucosa (P＜0.01). The number of E. Coli labeled with acridine orange in MLN increased significantly (P＜0.01) in OJ group. Mucosa injury and the number of bacteria were reduced by glutamine. Conclusion Glutamine may help to maintain the mucosal barrier function and reduces bacterial translocation in OJ.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 26-27 )