Protective effects on ischemic myocardium produced by partial reduction of bloodsupply combined with electrical stimulation of the gastrocnemius muscle in the rabbit
Ren Jianghua
Wang Zhiquan
Kuang Yongdong
Abstract：Objective To determine whether partial reduction of blood supply combined with stimulation of the gastrocnemius muscle in the rabbit has protective effects on ischemic myocardium, and to study its mechanism. Methods Thirty - two rabbits were randomly divided into four groups: control group( A group), muscle stimulation group( B group),femoral artery stenosis group(C group), muscle stimulation with femoral artery stenosis group (D group). Heart rate ,changes in left ventricular functions, nitric oxide (NO) and nitric oxide synthase (NOS) in serum from left ventricle were investigated. Results During coronary occlusion, there were no differences in heart rate in all groups, but during reperfusion , heart rates in group C and group D were slower than those of group A and group B (all P<0.05); compared with other three groups, muscle stimulation with femoral stenosis preconditioning would ①improve the systolic functions of the damaged left ventricle (all P<0.05) hearly back to the baseline;②decrease NO and NOS in serum of left ventricle (all P<0.05). Conclusion The romate preconditioning model which reduce blood supply combined with rapid stimulation of the gastrocnemius muscle has protective effects on ischemic myocardium, Probably related to the changes in NO.
Keywords：Preconditioning Gastrocnemnis muscle Myocardium Reperfusion injury Nitric oxide Rabbit
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1005-1007 )