Relationship between diabetic retinopathy and calcitonin gene related peptide and endothelin in diabetes mellitus
Su Ke
LongYan
Hu Yongling
Abstract：Objective To study the relationship between diabetic retinopathy (DR) and calcitonin gene related peptide (CGRP)or endothelin (ET) in diabetes rnellitus. Methods The concentration of calcitonin gene related peptide and endothelin was determinedin 30 normal subjects(group C) and 60 diabetic patients(DM group) by radioimmunoassay . The DM group was sub- divided into threegroups: 20 cases of non diabetic retinopathy group (DM group Ⅰ ); 22 cases of background diabetic retinopathy group (DM group Ⅱ ); 18cases of proliferative diabetic retinopathy group (DM group Ⅲ ). Results The concentration of calcitonin gene related peptide in diabetesmellitus group was lower than that in group C( P < 0.05), the CGRP in DM group Ⅲ was markedly lower than that in group C ( P <0.01) .The development of diabetic retinopathy was associated with lower CGRP level. ET in diabetes mellitus was higher than that ingroup C, but was not significantly increased in DM group and DM group Ⅰ ( P > 0.05). The ET in DM group Ⅲ was markedly higherthan that in group C( P < 0.01). There was a positive correlation between serum EＴ and Ins in diabetes mellitus. There was a negativecorrelation between CGRP and ET in diabetes mellitus. Conclusion Depressed CGRP may be related diabetic retinopathy. Marked de-crease in CGRP and increase in ET may be associated with diabetic retinopathy.
Keywords：Diabetic retinopathy Calcitonin gene related peptide Endothelins
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 740-741 )