Expressions of Fas system and its relationship with apoptosisin astrocytomas
Abstract：Objective To investigate the expression of Fas or FasL and their relationship with apoptosis in astrocytomas. Meth-ods Immunohistochemical method was used to detect the expression of Fas and FasL by TUNEL technique and apoptosis index (AI) wascalculated in 41 astrocytomas. Results Twenty- seven of the astrocytoms(66% ) expressed Fas. The amount of cells positive for Faswas small. 83% astrocytomas(34 of 41 ) showed complete loss of Fas expression or expression in < 5% of tumor cells. Thirty - two of theastrocytomas (78%) expressed FasL. In contrast, the percentage of positive is mom, with 46% astrocytomas ( 19 of 41) having positivecells greater than 5 %、 AI of astocytomas was 1.09 ± 0.48. The positive expression of Fas/FasL is not significantly related to apoptosis inastrocytomas. Conclusion Fas and FaL are important to the pathogenesis and development of astrocytomas. The development and pro-gression is related to abnormality of apoptosis. The weak expression of Fas may contribute to astrocytomas escaping from clearance by self- immnune system. Further study on the mechanism of astrocytoma apoptosis is needed
Keywords：Astrocytomas Fas FasL Apoptosis
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 735-737 )