Research Progress on Multiple Drug Resistance of Klebsiella Pneumoniae Originated from Animals

FU Dejia; ZENG Xianjun; KANG Huahua; HUANG Weiqian; PENG Xinyu

doi:10.19978/j.cnki.xmsy.2023.06.04

Abstract：Klebsiella pneumoniae is a worldwide opportunistic pathogen,which carries a variety of drug resistance genes.In addition to being a common iatrogenic infection pathogen in human,more and more studies have showed that it also caused invasive infections in animals.In this paper,the recent progress of antimicrobial resistance of Klebsiella pneumoniae originated from animals was reviewed,including drug resistance,drug resistance genes and control strategies.Klebsiella pneumoniae can carry multiple plasmids and be able to capture plasmids with drug resistance genes from the environment in various ways and spread them between the environment and animals,making it the"collector"of drug resistance genes,as well as the"key amplifier"and"transmitter".At present,the drug resistance of Klebsiella pneumoniae originated from animals is very serious,Klebsiella pneumoniae is resistant to almost all antibiotics in varying degrees,including β-lactam antibiotics,fluoroquinolones antibiotics and aminoglycoside antibiotics and etc..Some strains carry resistance genes such as extended-spectrum β-lactamases(ESBLs)and carbapenemases(CREs)making them pan-drug resistant strains.Studies have been carried out on plant extracts,bacteriophage and gene editing in order to find new solution to this problem.For example,it has been found that extracts from some kinds of plants have the characteristics of anti-bacteria,anti-inflammation and immune enhancement.Gene editing technology could be used to knock out specific drug resistance genes,and some bacteriophages can specifically kill Klebsiella pneumoniae originated from animals.These studies bring new hopes for the clinical treatment and control of Klebsiella pneumoniae related diseases.