Identification and evaluation of a surface protective antigen, SzP of Streptococcus equi ssp. zooepidemicus
Abstract：Streptococcus equi ssp. zooepidemicus （SEZ） is an important pathogen associated with opportunistic infections of pigs in China. The absence of suitable vaccines or the knowledge of virulence markers could block the step for controlling SEZ infection. M-like protein （SzP） has been identified as an immunogenic protein in the previous study but its protective efficacy was not clear. In the present study, the purified recombinant SzP could elicit a significant humoral antibody response and could confer significant protection against challenge with lethal dose of SEZ in mice model. In addition, the SzP was an in vivo-induced antigen confirmed by the real-time PCR and could induce significant Thl-/Th2-immune responses. Our findings suggested that SzP played an important role in the pathogenesis of SEZ and could be a target for the development of an effective vaccine against SEZ infection.
Keywords：Streptococcus equi ssp. zooepidemicusSzPVaccine candidate
Publication Date：2012-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 30-33 )