Relationship between magnetic resonance T2FLAIR,DWI and SWI sequence imaging characteristics and cognitive function and motor disorder in patients with cerebral small vessel disease

SU Cen; JIN Biao; QIAN Jinjun; XIA Haiping; ZHANG Weifang; YAN Jianchun

doi:10.12122/j.issn.1674-4500.2026.02.17

Abstract：Objective To analyze the relationship between imaging characteristics of MRI T2 FLAIR,DWI and SWI sequences and cognitive function and motor disorders in patients with cerebral small vessel disease(CSVD).Methods A total of 110 patients with CSVD admitted from March 2023 to March 2024 were included and their data were retrospectively analyzed.All patients received MRI examination and cognitive function[Montreal Cognitive Assessment Scale(MoCA)]and motor dysfunction[Tinetti Performance Oriented Mobility Assessment(POMA)]assessment.According to the MoCA score,they were divided into cognitive disorder group and control group 1,and the MoCA score and MRI characteristics scores[lacunar infarction(LI),white matter lesions(WML),cerebral microbleeds(CMBs)and enlarged perivascular spaces(EPVs)]were compared between groups.According to the POMA score,the patients were classified into motor disorder group and control group 2,and the POMA score and MRI characteristics scores(LI,WML,CMBs,EPVs)were compared.Pearson correlation analysis model was used to analyze the correlation between LI,WML,CMBs,EPVs and MoCA score and POMA score.ROC curve was drawn to analyze the efficiency of MRI characteristics on predicting cognitive disorder and motor disorder in patients with CSVD.Results The characteristic scores of LI,WML,CMBs and EPVs in cognitive disorder group were significantly higher than those in control group 1(P<0.05).The characteristics scores of LI,WML,CMBs and EPVs in motor disorder group were significantly higher compared to control group 2(P<0.05).According to Pearson correlation analysis model,the characteristics scores of LI,WML,CMBs and EPVs were negatively correlated with MoCA score and POMA score(P<0.05).The AUC,sensitivity and specificity of combination of the above indicators were 0.885,72.88%and 98.04%in predicting cognitive disorder in patients with CSVD,and were 0.911,87.23%and 84.13%in predicting motor disorder in patients with CSVD.Conclusion Multi-sequence imaging characteristics of T2 Flair,DWI and SWI are more clinically systematic than traditional single-sequence studies.The characteristics of LI,WMH,CMBs and EPVs are closely related to cognitive and motor disorders,providing a basis for early clinical identification of cognitive and motor disorders risks and formulation of targeted intervention strategies.