Value of RS-EPI with ultra-high b-values diffusion-weighted imaging sequence in differentiating prostate cancer from benign prostatic hyperplasia
SU Yeming
JING Yueyue
MENG Xinxin
JIA Yongjun
YU Nan
MA Guangming
YANG Chuangbo
Abstract：Objective To assess the value of segmental readout diffusion-weighted imaging sequence(RS-EPI)ultra-high b-values in differentiating prostate cancer(PCa)from prostate hyperplasia(BPH).Methods Thirty-seven patients with prostate diseases(15 PCa patients and 22 BPH patients)diagnosed at the Affiliated Hospital of Shaanxi University of Chinese Medicine from March 2022 to April 2023 were retrospectively collected.All patients underwent preoperative RS-EPI DWI scans(b=0,1000,2000,3000 s/mm²)using a Siemens Skyra 3.0T MRI system.Two senior radiologists independently observed the images at each b-value under a double-blind method,measured the signal intensity of the DWI hyperintense areas and the adjacent muscle tissue and calculated the qualitative diagnostic accuracy of DWI for PCa and BPH at each b-value.Results At b-values of 1000,2000 and 3000 s/mm²,the sensitivities of DWI for diagnosing prostate cancer were 80.0%,93.3%and 93.3%,respectively,while the specificities for benign prostatic hyperplasia were 63.6%,68.2%and 72.7%,respectively.The area under the curve(AUC,95%CI)values were 0.852(0.732-0.972),0.882(0.782-0.982)and 0.939(0.872-0.999),respectively.Diagnostic performance at a b-value of 1000 s/mm² was inferior to that at 2000 and 3000 s/mm²(P<0.05).Conclusion The selection of ultra-high b-values(b=2000,3000 s/mm²)demonstrates high sensitivity and specificity in differentiating PCa from BPH,suggesting its potential as an important auxiliary diagnostic method.
Keywords：prostatic neoplasmsprostatic hyperplasiamagnetic resonance imagingdiffusion weighted imagingdiagnosisdifferential
Publication Date：2026-02-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：6( 238-243 )