Impact of varying degrees of coronary artery stenosis on left ventricular dysfunction:based on myocardial work technology

LIU Yong; SUN Aitong

doi:10.12122/j.issn.1674-4500.2026.02.13

Abstract：Objective To investigate the effect of different degrees of coronary artery stenosis on left ventricular dysfunction and its clinical diagnostic value in coronary heart disease by myocardial work.Methods A total of 114 patients with coronary heart disease who underwent coronary angiography in the Department of Cardiology of the People's Hospital of Inner Mongolia Autonomous Region from September 2023 to April 2025 were selected and divided into coronary heart disease group(n=80)and control group(n=34)according to the results of coronary angiography.According to the degree of stenosis,the CHD group was divided into mild to moderate stenosis group(50%<stenosis rate<75%,n=40)and severe stenosis group(stenosis rate>75%,n=40).All patients underwent conventional echocardiography(TTE)and two-dimensional speckle tracking echocardiography(2D-STE).Left ventricular longitudinal strain(GLS)and myocardial work related parameters were analyzed to evaluate the effect of different degrees of coronary stenosis on left ventricular function.Results Compared with the control group,GLS,GWI,GWE and GCW in the coronary heart disease group were significantly decreased,and GWW was significantly increased;Compared with the mild-to-moderate group,GLS,GWI,GWE and GCW were lowe and GWW was higher in the severe group.ROC curve showed that the area under the curve of GWI,GCW,GWE and GWW were 0.71,0.74,0.84 and 0.81,respectively.The cut-off value of GWE was 89.5%,and the sensitivity,specificity and Youden index for predicting CHD were 70%,87.5%and 0.58,respectively.Conclusion When myocardial work was used to assess left ventricular function in patients with different degrees of coronary artery stenosis,GWE shows the highest correlation with the severity of the disease and the optimal diagnostic performance.