Molecular imaging of pancreatic cancer with a cannabinoid type 2 receptor targeted PET probe
JIN Can
CAO Xinghai
CHEN Junwei
XIE Linghua
MAO Dilong
HE Qinggang
Abstract：Objective To develop a novel PET probe(18F-JR-1002)targeting the cannabinoid type 2 receptor(CB2R)for the molecular imaging diagnosis of pancreatic ductal adenocarcinoma(PDAC).Methods 18F-JR-1002 was designed and synthesized based on a CB2R inverse agonist structure.Radiolabeling was performed using an automated synthesizer(OnePlatform V3.1s),and its radiochemical yield,molar activity,and in vitro stability were determined.An orthotopic PDAC mouse model was established using PANC-2-luc cells.MicroPET/CT imaging was utilized to assess probe uptake in tumor tissues,which was compared with that in normal mice.Results The radiochemical yield of ¹⁸F-JR-1002 was 34.7%±8.1%,with a molar activity of 264.5±41.2 GBq/µmol.It demonstrated excellent in vitro stability(>95%over 3 h).MicroPET imaging revealed significantly higher probe uptake in the pancreatic region of PDAC mice compared to the normal group(P=3.34×10-9),indicating the probe's specific recognition of CB2R,which is highly expressed in PDAC tissues.Conclusion This study successfully developed a highly stable and affine CB2R-targeted PET probe that specifically identifies PDAC,providing a new molecular imaging tool for early diagnosis and treatment efficacy evaluation.
Keywords：cannabinoid receptor type Ⅱpositron emission tomographyradioactive tracerpancreatic cancerdiagnosis
Publication Date：2026-02-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：6( 141-146 )