Research progress in the use of renal-cleared gold nanoparticles as CT contrast agents
YU Hanmiao
JIANG Xingya
Abstract：Renal-cleared gold nanoparticles(AuNPs)have gradually gained widespread attention in medical imaging as CT contrast agents due to their excellent physicochemical properties and high X-ray attenuation coefficients.This review explores the physicochemical properties of AuNPs,their renal clearance mechanisms,and their applications in CT imaging.It was found that factors such as the size and surface charge of AuNPs had a significant effect on their renal clearance efficiency,and smaller AuNPs were able to be cleared more efficiently through the kidneys and improve the contrast of CT imaging.Finally,it discusses the controversial safety of long-term use of gold nanoparticles,cost-benefit analysis,and looks forward to future research directions and potential applications,summarizing the existing results and pointing out that the safety and cost are still to be verified.
Keywords：renal clearancegold nanoparticlesCT contrast agentsnanoparticle designbiomedical application
Publication Date：2026-01-20
Online Publishing Date：2026-02-04(First online date of this platform, not the publication date of the document)
Pages：8( 127-134 )