Clinical value of left ventricular pressure-strain loop technology in assessing catheter ablation efficacy in patients with mitral regurgitation
ZHANG Pei
LI Ru
XIE Qing
ZHENG Xiaoye
WU Xiaojuan
Abstract：Objective To investigate the value of left ventricular pressure-strain loop(LV-PSL)technology in assessing the efficacy of catheter ablation for patients with atrial functional mitral regurgitation.Methods A total of 142 patients with atrial functional mitral regurgitation who underwent first-time catheter ablation in our hospital from April 2021 to May 2024 were enrolled.Echocardiographic re-evaluation was performed 6 months after treatment,and patients were stratified into the improvement group(n=68)and non-improvement group(n=74)according to the presence or absence of improvement in atrial functional mitral regurgitation.LV-PSL technology was applied to measure LV-PSL parameters[global longitudinal strain(GLS),global myocardial work efficiency(GWE),global wasted work(GWW),global constructive work(GCW),and global myocardial work index(GWI)]before treatment and 6 months post-treatment.Intergroup comparisons of LV-PSL parameters were conducted.ROC curve analysis was used to evaluate the performance of LV-PSL parameters in predicting the efficacy of catheter ablation for atrial functional mitral regurgitation.Multivariate logistic stepwise regression analysis was performed to identify independent influencing factors of treatment efficacy in patients with atrial functional mitral regurgitation.Results Compared with pre-treatment,both groups exhibited significant increases in GLS,GWE,GCW,and GWI,as well as a significant decrease in GWW at 6 months post-treatment(P<0.05).Before treatment and at 6 months post-treatment,GLS,GWE,GCW,and GWI in the non-improvement group were significantly lower than those in the improvement group,whereas GWW was significantly higher(P<0.05).ROC curve analysis showed that the area under the curve(AUC)values of GLS,GWE,GWW,GCW,and GWI for assessing the efficacy of catheter ablation in patients with atrial functional mitral regurgitation were 0.843,0.862,0.726,0.789,and 0.891,respectively.And the AUC of the five combined assessments was 0.907.Patients in the non-improvement group had significantly higher age,CHA2DS2-VASc score,proportion of persistent atrial fibrillation,proportion of severe mitral regurgitation,left atrial anteroposterior diameter(LAD),and mitral annular anteroposterior diameter(MAD)compared with the improvement group(P<0.05).Multivariate analysis showed that age,atrial fibrillation type,mitral regurgitation degree,MAD,GWE,and GWI were independent predictors of the efficacy of catheter ablation in patients with atrial functional mitral regurgitation(P<0.05).Conclusion LV-PSL technology serves as a valid tool for the early assessment of catheter ablation efficacy in patients with atrial functional mitral regurgitation,and the LV-PSL parameters GWE and GWI are independent predictors of the efficacy of catheter ablation in patients with atrial functional mitral regurgitation.
Keywords：atrial fibrillationmitral regurgitationechocardiographyleft ventricular pressure-strain loopcatheter ablationefficacyevaluation value
Publication Date：2026-01-20
Online Publishing Date：2026-02-04(First online date of this platform, not the publication date of the document)
Pages：7( 114-120 )