Abnormal spontaneous neural activity and functional connectivity in sensorimotor and visuospatial brain regions of Parkinson's disease patients:a resting-state fMRI study
LIN Bixia
WANG Yapeng
ZHAO Beibei
CUI Xiaofeng
ZHANG Jiawen
HU Tao
LIANG Hengrui
Abstract：Objective To investigate the patterns of altered local brain activity and global connectivity in Parkinson's disease(PD)patients using a combined regional homogeneity(ReHo)and functional connectivity(FC)analysis approach.Methods Twenty-nine patients and 29 age-,gender-,and education-matched healthy controls(HCs)were enrolled from the Seventh Clinical College of Guangzhou University of Chinese Medicine(Shenzhen Bao'an District Traditional Chinese Medicine Hospital)from December 2023 to September 2024.All subjects underwent clinical assessments and resting-state functional magnetic resonance imaging(rs-fMRI)scanning.ReHo was used to detect alterations in local brain activity in patients with PD.Brain regions exhibiting significant ReHo differences were selected as regions of interest for seed-based FC analysis,thereby enabling the identification of whole-brain connectivity changes.Correlation analysises were used to explore the relationships between abnormal ReHo and FC values and clinical indicators such as the Movement Disorder Society-Unified Parkinson's Disease Rating Scale Part Ⅲ(MDS-UPDRS Ⅲ),Mini-Mental State Examination(MMSE),and disease duration.Results Compared with HCs,the PD patients showed reduced ReHo values in the right superior temporal gyrus and the left supramarginal gyrus(GRF corrected,voxel P<0.005,cluster P<0.05).A whole-brain voxel-wise FC analysis revealed that the right superior temporal gyrus was less connected to the left calcarine gyrus,left postcentral gyrus,left medial and paracingulate gyri,and the right rolandic operculum gyrus in the PD group.Additionally,the left supramarginal gyrus exhibited reduced FC with both the left lingual gyrus and the right rolandic operculum gyrus(GRF corrected,voxel P<0.005,cluster P<0.05).Correlation analyses revealed that in PD patients,the ReHo values in the right superior temporal gyrus(r=-0.417,P=0.024)and left supramarginal gyrus(r=-0.468,P=0.010)were negatively correlated with MDS-UPDRS Ⅲ scores.Conversely,ReHo in the right superior temporal gyrus(r=0.471,P=0.010)and left supramarginal gyrus(r=0.481,P=0.008)showed positive correlations with MMSE scores.Furthermore,FC analysis indicated a positive correlation between the right rolandic operculum and MMSE scores(r=0.369,P=0.048).Conclusion Patients with Parkinson's disease exhibit abnormal neuronal activity in brain regions involved in sensorimotor integration and visuospatial processing.Imbalances in the functional integration of these brain regions may be associated with worsening motor and non-motor symptoms in PD.
Keywords：Parkinson's diseaseresting-state functional magnetic resonance imagingregional homogeneityfunctional connectivity
Publication Date：2026-01-20
Online Publishing Date：2026-02-04(First online date of this platform, not the publication date of the document)
Pages：7( 87-93 )