The application of two-dimensional speckle tracking imaging combined with myocardial work technique to evaluate left ventricular systolic function in patients with pulmonary heart disease and right heart failure
WANG Jie
FENG Dexi
Abstract：Objective To investigate alterations in left ventricular(LV)systolic function in patients with moderate to severe cor pulmonale during right heart decompensation,utilizing two-dimensional speckle-tracking echocardiography(2D-STE)combined with non-invasive myocardial work(MW)assessment,and to explore the clinical application value of this approach.Methods This study enrolled 30 patients with moderate to severe cor pulmonale(case group)and 30 age-and gender-matched healthy volunteers(control group)from the Inner Mongolia Autonomous Region People's Hospital from April 2023 to April 2025.All participants underwent standard echocardiographic examination,followed by analysis using 2D-STE integrated with MW.Differences in various parameters between the two groups were compared to elucidate changes in LV myocardial work in the patient group.The primary parameters assessed included:LV global longitudinal strain(GLS),LV global work index(LVGWI),LV global constructive work(LVGCW),LV global wasted work(LVGWW),and LV global work efficiency(LVGWE).Results Comparison of conventional echocardiographic parameters revealed that the case group had significantly larger left atrial size,thicker interventricular septum,wider pulmonary artery diameter,and higher pulmonary artery pressure compared to the control group(P<0.05),alongside a mild reduction in LV ejection fraction(LVEF,P<0.05).Analysis of myocardial work parameters demonstrated that the case group exhibited significantly increased GWW(P<0.01)and decreased GLS,GWI,GWE and GCW(P<0.01).Correlation analysis indicated that LV GWI and GCW were negatively correlated with pulmonary artery diameter(r=-0.314,-0.256,P<0.05).GWE,GWI,and GCW showed positive correlations with LVEF(r=0.417,0.452,0.445,P<0.05)and negative correlations with GLS(r=-0.813,-0.835,-0.685,P<0.05).Conversely,GWW was positively correlated with GLS(r=0.439,P<0.05).Conclusion Myocardial work assessment provides precise quantitative parameters of LV myocardial work in patients with moderate to severe cor pulmonale.The results confirm that alterations in LV systolic function occur during the subclinical stage,offering innovative and reliable data to support early clinical intervention for this condition.
Keywords：echocardiographymyocardial work techniquesright-sided heart failurethe two ventricles interact with each other
Publication Date：2026-01-20
Online Publishing Date：2026-02-04(First online date of this platform, not the publication date of the document)
Pages：7( 74-80 )