Correlation analysis of echocardiographic coronary artery Z-score with heart rate,inflammatory markers,and blood component indices in children with Kawasaki disease
YAN Xiaohua
ZHANG Taiming
GAO Na
MU Zhilong
HE Wang
WAN Xuan
SUN Yanan
MA Juan
Abstract：Objective To analyze the correlation between coronary artery Z-scores measured by echocardiography and heart rate,inflammatory indicators,and blood component indices in children with Kawasaki disease.Methods A total of 233 children with Kawasaki disease admitted to Shaanxi Provincial People's Hospital from March 2022 to March 2025 were enrolled as research subjects.Echocardiography was performed to measure the internal diameters of 6 coronary artery segments,including the left main coronary artery(LMCA),left anterior descending artery(LAD),left circumflex artery(LCX),proximal right coronary artery(RCA),middle RCA,and distal RCA.Z-scores for each vessel segment were calculated,and the maximum Z-score was used as the evaluation index for each child.According to the Z-scores,the children were divided into three groups:Dilatation group(2≤Z-score<2.5),Small coronary aneurysm group(2.5≤Z-score<5),and Medium-large coronary aneurysm group(Z-score≥5).General data of children in each group[gender,age,height,weight,body surface area(BSA),heart rate,fever duration]were collected,and the levels of biochemical indicators[platelets(PLT),C-reactive protein(CRP),white blood cell count(WBC),erythrocyte sedimentation rate(ESR),red blood cell count(RBC),neutrophil percentage(NE%),albumin(ALB),hemoglobin(HGB)]were detected.Correlations between general data,biochemical indicators and Z-scores were analyzed,and multiple linear regression analysis was performed to screen for independent risk factors affecting Z-scores.Results Compared with the Dilatation group and Small coronary aneurysm group,the Medium-large coronary aneurysm group had significantly higher levels of PLT,CRP,WBC,ESR,and NE%(P<0.05),and significantly lower levels of RBC,ALB,and HGB(P<0.05).Z-scores were positively correlated with heart rate,PLT,CRP,WBC,ESR,and NE%(P<0.05),and negatively correlated with RBC,ALB,and HGB(P<0.05).Multiple linear regression analysis showed that CRP(β=0.464),ESR(β=0.198),NE%(β=0.163),and ALB(β=-0.103)had a significant impact on Z-scores(P<0.001).Conclusion CRP,ESR,NE%,and ALB have independent predictive effects on coronary artery Z-scores,and can serve as predictive indicators for evaluating the severity and degree of dilation of coronary artery lesions in children with Kawasaki disease.
Keywords：Kawasaki diseaseechocardiographycoronary artery Z-scorediagnosisinflammationblood components
Publication Date：2026-01-20
Online Publishing Date：2026-02-04(First online date of this platform, not the publication date of the document)
Pages：8( 7-14 )