Value of gadoxetate disodium-enhanced MRI in the diagnosis of focal liver lesions
XIONG Bo
LI Yulin
ZHOU Xiaoqi
LI Rong
YANG Rihui
Abstract：Objective To investigate the hepatobiliary phase manifestations and pathological basis of gadoxetic acid disodium-enhanced MRI(Gd-EOB-DTPA-enhanced MRI)in focal liver lesions,and to provide more reference information for the differential diagnosis of focal liver lesions.Methods A retrospective analysis was performed on the clinical and Gd-EOB-DTPA-enhanced MRI data of 110 patients with surgically and pathologically confirmed focal liver lesions in Meizhou People's Hospital from January 2016 to May 2019.Pathological confirmation revealed 66 cases of hepatocellular carcinoma(HCC),12 cases of intrahepatic cholangiocarcinoma(ICC),3 cases of combined hepatocellular-cholangiocarcinoma(cHCC-CC),17 cases of metastases,1 case of primary hepatic squamous cell carcinoma,1 case of primary hepatic lymphoma,1 case of hepatic focal nodular hyperplasia(FNH),3 cases of hepatic regenerative nodules,1 case of hepatic adenoma,4 cases of hepatic cavernous hemangioma,and 1 case of hepatic angiomyolipoma,and the relationship between hepatobiliary phase manifestations and pathological basis was analyzed.Results On the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI:13 cases(13/66,20%)of HCC showed isointense to hyperintense signals,and 53 cases(53/66,80%)of HCC showed obviously hypointense signals.Nine cases(9/12,75%)of ICC presented hypointense signals with flocculent slightly hyperintense foci.Nine cases(9/17,52%)of metastatic liver cancer showed hypointense signals with central hyperintense signals.The 3 cases of cHCC-CC showed hypointense signals with central cloud-like hyperintense signals,central cloud-like hyperintense signals with peripheral hyperintense signals,and peripheral hyperintense signals with central hypointense signals,respectively.Among the 3 cirrhotic regenerative nodules,2 cases showed hypointense signals and 1 case showed hyperintense signals.The 4 cases of cavernous hemangioma presented hypointense signals.The 1 case of FNH showed ring-shaped hyperintense signals with a central"target sign"of slightly hyperintense signals.The 1 case of primary lymphoma showed hypointense signals with central dendritic hyperintense signals.The 1 case of hepatic angiomyolipoma,1 case of hepatic adenoma,and 1 case of primary squamous cell carcinoma all showed hypointense signals.The hepatobiliary phase manifestations of focal liver lesions varied according to the pathological conditions within the lesions.Conclusion Fully understanding the hepatobiliary phase manifestations of Gd-EOB-DTPA-enhanced MRI and their pathological basis is helpful for the differential diagnosis of focal liver lesions and has important clinical application value.
Keywords：gadoxetate disodiumfocal liver lesionshepatobiliary phaseimaging
Publication Date：2025-12-20
Online Publishing Date：2026-01-07(First online date of this platform, not the publication date of the document)
Pages：7( 1563-1569 )