Hemodynamic features in atherosclerosis with intracranial aneurysms and its relationship with subarachnoid hemorrhage risk
JI Ruoshi
YAN Chunchun
LIU Sanchun
ZOU Xuan
YAO Jia
XU Jiali
Abstract：Objective Based on head and neck CT angiography imaging data,this study aimed to apply computational fluid dynamics technology to analyze the influence of atherosclerosis(AS)on the hemodynamics of intracranial aneurysms and explore its guiding value for clinical evaluation.Methods A retrospective analysis was conducted on the clinical data of 178 patients with intracranial aneurysms admitted to The Second Affiliated Hospital of Bengbu Medical University from June 2023 to January 2025.Patients were divided into four groups based on the presence of AS and the occurrence of subarachnoid hemorrhage(SAH):intracranial aneurysm(IA)group,AS+IA group,SAH group,and AS+SAH group.All patients underwent head and neck CT angiography examinations.Three-dimensional vascular models were reconstructed,and computational fluid dynamics simulations were performed to calculate hemodynamic parameters including wall shear stress(WSS),time-averaged wall shear stress(TAWSS),oscillatory shear index(OSI),relative residence time,and blood flow velocity.Hemodynamic differences between AS-complicated aneurysms and simple aneurysms were compared,and their correlation with SAH was analyzed.Results No significant difference in aneurysm size was observed between groups(P>0.05).The aspect ratio(AR)and size ratio(SR)were significantly higher in the AS group than in the non-AS group(P<0.05),and SAH patients also showed significantly higher AR and SR values than non-SAH patients(P<0.05).Hemodynamic analysis revealed significantly increased blood flow velocity and OSI values,along with decreased TAWSS and normalized WSS in the AS group(P<0.05).Similar hemodynamic alterations were observed in SAH patients.Conclusion Through numerical simulation and imaging analysis,AS significantly altered the hemodynamic characteristics of intracranial aneurysms,manifested as increased blood flow velocity,elevated OSI,and reduced WSS.These changes were closely associated with an increased risk of aneurysm rupture.Computational fluid dynamics technology can provide important reference for clinical evaluation of aneurysm stability and SAH risk prediction.
Keywords：atherosclerosisintracranial aneurysmhemodynamicssubarachnoid hemorrhage
Publication Date：2025-10-20
Online Publishing Date：2025-11-24(First online date of this platform, not the publication date of the document)
Pages：7( 1198-1204 )