Research advances in MRI-based mechanistic analysis and intervention strategies for sarcopenia
DING Xuexiu
LI Xiaokai
Abstract：With the acceleration of global population aging,sarcopenia has developed into a significant public health problem that seriously affects the health and quality of life of the elderly.The refined application of MRI provides a new perspective to reveal the microscopic pathological changes in the muscle.Advanced MRI techniques,including Dixon imaging,DTI,T2-mapping,and MRS,enable the quantitative assessment of critical parameters such as intramuscular fat infiltration,fibrosis,and energy metabolism.These methodologies provide a robust theoretical foundation for the early diagnosis,mechanistic analysis,and intervention strategies for sarcopenia.Moreover,sleep and physical activity serve as fundamental pillars for skeletal muscle recovery,repair and growth,promoting anabolic hormone secretion,optimizing protein synthesis conditions,inhibiting catabolic processes,and reducing inflammation.Consequently,by elucidating the intrinsic relationship between sleep,physical activity,and muscle health,and integrating MRI as a non-invasive and quantitative assessment tool for muscle mass,composition and structural changes,this paper establishes a rigorous scientific basis for the early detection,risk stratification,and personalized management of sarcopenia.
Keywords：sarcopeniamagnetic resonance imagingsleepskeletal musclephysical activity
Publication Date：2025-09-20
Online Publishing Date：2025-10-22(First online date of this platform, not the publication date of the document)
Pages：6( 1180-1185 )