Evaluation of the effect of hyperthyroidism on myocardial mechanics in hypertensive patients using speckle tracking imaging

GAO Xuhong; ZHAO Ruihuan; WANG Ruiqi; XUE Jiping

doi:10.12122/j.issn.1674-4500.2025.09.14

Abstract：Objective To evaluate the impact of hyperthyroidism on myocardial mechanics in hypertensive patients using two-dimensional speckle tracking imaging(2D-STI).Methods A retrospective analysis was conducted on 75 hypertensive patients who visited our hospital from April to December 2023.They were divided into two groups based on the presence of comorbid hyperthyroidism:hypertension-only group(n=38)and the hypertension with hyperthyroidism group(n=37).Additionally,32 healthy volunteers were selected as the control group.All participants underwent 2D-STI to measure left ventricular global longitudinal strain across three myocardial layers:GLS-endo,GLS-mid and GLS-epi.Strain parameters were compared among groups.Results The longitudinal strain in each layer of the hypertension with hyperthyroidism group was significantly lower than that in the hypertension-only group and the control group(-18.29±2.40 vs-19.68±2.10 vs-22.60±2.38,-16.60±2.55 vs-18.01±2.12 vs-22.09±2.72,-15.60±2.33 vs-16.78±2.28 vs-20.54±1.42,P<0.05).Notably,the reduction in GLS-endo was more pronounced than that in GLS-mid and GLS-epi(-18.29±2.40 vs-16.60±2.55 vs-15.60±2.33,P<0.05).Conclusion This study utilized two-dimensional speckle tracking imaging to stratify and quantify myocardial strain parameters,revealing a transmural gradient injury from the endocardial layer through the myocardial layer to the epicardial layer in the left ventricle of hypertensive patients with hyperthyroidism.These findings provide sensitive imaging evidence for the early identification of subclinical cardiac dysfunction and suggest that clinicians should pay special attention to hypertensive patients with concurrent hyperthyroidism.