Clinical application progress of low-dose CT myocardial perfusion in the diagnosis and treatment of coronary heart disease
JING Yueyue
JIA Yongjun
Abstract：The accurate diagnosis and treatment of coronary artery disease rely on the evaluation of myocardial microcirculation and function.However,the traditional myocardial computed tomographic perfusion(CTP)has limited its clinical application due to the high radiation dose(15-25 mSv).In recent years,through the integration of the third-generation dual-source CT,dynamic stress protocols and deep learning techniques,the radiation dose of CTP has been significantly reduced to 3.26 mSv(a 78%reduction),while the diagnostic specificity has been increased to 92%.Dynamic CTP combined with computed tomography angiography can simultaneously assess the coronary artery anatomy and myocardial perfusion function,achieving a"one-stop"diagnosis and avoiding 30%-50%of unnecessary invasive examinations.Artificial intelligence further optimizes the diagnostic process by automatically quantifying perfusion defects and predicting prognosis;multimodal integration(such as CTP+PET)increases the diagnostic sensitivity and specificity to 95%and 92%respectively.This article systematically reviews the technological progress,clinical application value and future directions of low-dose CTP,providing an evidence-based basis for optimizing the accurate diagnosis and treatment of coronary artery disease.
Keywords：low-dose CT myocardial perfusioncoronary artery diseasedynamic imagingartificial intelligencemultimodal integration
Publication Date：2025-08-20
Online Publishing Date：2025-09-22(First online date of this platform, not the publication date of the document)
Pages：6( 1034-1039 )