Application of diffusion tensor imaging in the pathological process of Alzheimer's disease
LI Xinlu
ZHANG Hanxi
YANG Ming
CHU Bingyuan
SHANG Qingqing
LI Weiqing
FENG Ze
WANG Feng
Abstract：Alzheimer's disease(AD),as an irreversible chronic neurodegenerative disorder,early diagnosis and intervention are crucial for delaying the disease progression.Diffusion tensor imaging(DTI),an important branch of MRI,can non-invasively assess the microstructural changes of brain tissue,providing unique value for the early diagnosis and pathological mechanism research of AD.This study will review several aspects including the pathological mechanism of AD,the principle and parameters of DTI,the changes of DTI parameters during the pathological process of AD,and the correlation between DTI parameters and the pathological development of AD,in order to explore the feasibility of using DTI parameters as clinical diagnostic indicators and their correspondence with disease stages,aiming to provide references for the early diagnosis and pathological mechanism research of AD.
Keywords：Alzheimer's diseasediffusion tensor imagingpathological processbiomarker
Publication Date：2025-08-20
Online Publishing Date：2025-09-22(First online date of this platform, not the publication date of the document)
Pages：6( 1028-1033 )