Evaluation value of 18F-FDG PET/CT delayed imaging in the drug efficacy of hepatic alveolar echinococcosis
AMINA·Yibulayin
QIN Yongde
BA Ya
ZHANG Qizhou
LI Yubin
LI Xiaohong
Abstract：Objective To explore the predictive value of 18F-FDG PET/CT delayed imaging for lesion growth rate in patients with hepatic alveolar echinococcosis(HAE)who were unresponsive to drug therapy.Methods The patients with HAE who underwent dual phase(early phase+delayed phase)18F-FDG PET/CT in the Department of Nuclear Medicine,the First Affiliated Hospital of Xinjiang Medical University from January 2014 to April 2024 were retrospectively collected.A total of 32 patients who did not undergo surgery and regularly took albendazole tablets(10 mg·kg-1·d-1)orally for a long time were analysed.The maximum standard uptake value(SUVmax),tumor to background ratios(TBR),infiltration zone width(W value)and maximum diameter of HAE lesions in 32 patients were compared before and after treatment.For these 32 patients,univariate and multivariate analyses were conducted using pre-treatment factors such as age,gender,lesion location,delayed-phase 18F-FDG PET/CT SUVmax,TBR,W value,maximum diameter as independent variables,with the annual growth rate of the lesion maximum diameter as the dependent variable.Results PET showed that the HAE lesions of 32 patients before and after drug treatment all exhibit ring-shaped hypermetabolism.After treatment,the SUVmax,TBR,and maximum lesion diameter in the delayed phase of PET/CT were greater than those before treatment(P<0.01);However,no significant differences were found in the overall distribution of W values before and after treatment(P>0.05).Among these 32 patients,The SUVmax,TBR and W value of infiltration zone before treatment were correlated with the annual growth rate of maximum diameter(P<0.001).SUVmax and TBR were highly positively correlated(P＜0.001),Thus,the SUVmax value and W value before treatment were included to predict the annual growth rate of maximum diameter of HAE.Both variables included in the model significantly influenced the annual growth rate of the HAE lesion maximum diameter(P<0.05).Conclusion Pre-treatment delayed-phase PET/CT SUVmax and W values are found to be predictive of the annual growth rate of lesions in patients with ineffective HAE drug treatment.
Keywords：hepatic alveolar echinococcosispositron emission tomographyfluorodeoxyglucose
Publication Date：2025-08-20
Online Publishing Date：2025-09-22(First online date of this platform, not the publication date of the document)
Pages：6( 940-945 )