Inferior vena cava ultrasound blood flow parameters combined with MMP-2 and VEGF can predict the efficacy of radiofrequency ablation for varicose veins of lower extremity
LI Zongyu
GUAN Hao
LAI Jingyue
ZHANG Ying
MA Jiancang
Abstract：Objective To investigate the value of inferior vena cava blood flow parameters by ultrasound detection combined with matrix metalloproteinase(MMP)-2 and vascular endothelial growth factor(VEGF)in predicting the curative effect of radiofrequency ablation(RFA)in varicose vein of lower extremity(VVLE).Methods A retrospective analysis was performed on the clinical data of eighty-two patients with VVLE who underwent RFA from October 2022 to October 2024 at The Second Affiliated Hospital of Xi'an Jiaotong University.After 3 months of postoperative follow-up,patients were divided into effective group(n=70)and ineffective group(n=12)according to the curative effect.The differences in inferior vena cava blood flow parameters(mean diameter,reflux time,mean reflux velocity,blood flow volume),MMP-2 and VEGF between the two groups were compared,and predictive value of combined detection with the above indexes for curative effect was analyzed by ROC curves.Results Age,proportion of diabetes mellitus,mean diameter,reflux time,mean reflux velocity,blood flow volume,positive expressions of MMP-2 and VEGF in ineffective group were higher than those in effective group(P<0.05).ROC curves analysis showed that AUC values of mean diameter,reflux time,mean reflux velocity,blood flow volume and combined detection were 0.827,0.837,0.848,0.821,and 0.915,respectively(P<0.05).The sensitivity,specificity and accuracy of inferior vena cava ultrasound blood flow parameters combined with MMP-2 and VEGF for predicting curative effect of RFA were 100.00%,90.00%and 91.46%,higher than those of single index.The results of multivariate Logistic regression analysis showed that age,diabetes mellitus,inferior vena cava dysfunction(any ultrasound blood flow parameter≥cut-off value),positive MMP-2 and positive VEGF were all risk factors affecting curative effect of RFA(P<0.05).Conclusion Predictive value of inferior vena cava ultrasound blood flow parameters combined with MMP-2 and VEGF is high for curative effect of RFA in VVLE patients.
Keywords：varicose vein of lower extremityradiofrequency ablationcurative effectinferior vena cavaultrasound blood flow parametermatrix metalloproteinase-2vascular endothelial growth factorpredictive value
Publication Date：2025-08-20
Online Publishing Date：2025-09-22(First online date of this platform, not the publication date of the document)
Pages：7( 933-939 )