Research progresses of MRI with advanced nanomaterials in diagnosis and treatment of the Amyloid-β hypothesis of Alzheimer's disease
QI Yuming
YAN Zhaoxiong
WANG Yixuan
ZHAO Ruobing
ZHU Zhaohong
YAN Chaoren
Abstract：Alzheimer's disease(AD)is a neurodegenerative disorder that severely threatens human health,with a highly complex pathogenesis.It is generally believed that extracellular deposition of Aβ and intracellular aggregation of tau protein,which form NFTs,are key factors influencing the onset of AD.Medical imaging techniques,especially MRI,are considered essential tools in the study of brain diseases,particularly AD.However,conventional MRI techniques have certain limitations in the early diagnosis of AD,such as low sensitivity and difficulty in specifically targeting biomarkers associated with AD and other related diseases.Nanomaterials,when used as MRI contrast agents,can enhance the imaging signals of affected brain regions,enabling accurate diagnosis and imaging of AD.In addition,nanomaterials have demonstrated controlled-release properties,targeting capabilities,and the ability to help drugs cross the blood-brain barrier in MRI-guided drug delivery systems.These features offer new possibilities for AD treatment,even enabling synergistic effects between the nanomaterials,thus achieving both diagnostic and therapeutic benefits.This paper systematically reviews recent advancements in the combination of MRI and nanomaterials for the early diagnosis and treatment of AD.It also provides an in-depth outlook on the future development of MRI-nanomaterial integration in AD diagnosis and therapy.
Keywords：Alzheimer's diseasenanoparticle therapyMRI
Publication Date：2025-07-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 897-904 )