Diagnostic value of dynamic contrast-enhanced MRI based on CDT-VIBE technique on liver space-occupying lesions
LIAN Yufei
PAN Zhenyu
YAN Yuchang
JIANG Yueluan
HUANG Zhongxia
Abstract：Objective To investigate the application value of dynamic contrast-enhanced MRI with 3.0T magnetic resonance CAIPIRINHA-Dixon-TWIST-VIBE technique in the diagnosis of hepatic space-occupying lesions.Methods A total of 98 patients with liver space-occupying lesions confirmed by pathology in the hospital were collected from December 2022 to December 2024.After admission,all patients received MRI plain scan and CDT-VIBE dynamic enhanced scan to obtain multi-phase images(water phase,fat phase,same/opposite phase)combined with qualitative enhancement mode scan images(arterial phase,portal phase,delayed phase characteristics).The quantitative parameters of dynamic enhanced MRI[peak time(Tpeak),transport constant(Ktrans),rate constant(Kep),signal-to-noise ratio(SNR),contrast-to-noise ratio(CNR)]were recorded.With pathology as the gold standard,the characteristics of MRI images and quantitative parameters of patients with different properties of liver space-occupying lesions were analyzed.Receiver operating characteristic curve was used to analyze the differential efficiency of dynamic enhanced MRI parameters on the properties of liver space-occupying lesions.Results Among the 98 patients with liver space-occupying lesions,45 cases were pathologically confirmed as benign lesions and 53 cases as malignant lesions.The proportion of high enhancement in the arterial phase,heterogeneous enhancement,capsular enhancement in the delayed phase and"fast-in and fast-out"model in malignant group were higher than those in benign group(P<0.05),and the marginal nodular enhancement,continuous enhancement and"progressive enhancement"model were more common in benign group(P<0.05).Ktrans,Kep,SNR and CNR in malignant group were higher than those in benign group(P<0.05),and Tpeak was shorter than that in benign group(P<0.05).ROC curve showed that the areas under the curves of Ktrans,Kep,Tpeak,SNR,CNR for differentiating benign and malignant liver space-occupying lesions were 0.842(95%CI:0.754-0.908,P<0.001),0.811(95%CI:0.720-0.883,P<0.001),0.809(95%CI:0.717-0.882,P<0.001),0.791(95%CI:0.697-0.866,P<0.001)and 0.768(95%CI:0.671-0.847,P<0.001).Ktrans had the highest efficiency,and when the cut-off value of Ktrans was>0.28 min-1,the Youden index,sensitivity and specificity were 0.570,79.25%,77.78%,respectively.Conclusion CDT-VIBE technique combined with qualitative enhancement model and quantitative perfusion parameters can help to identify benign and malignant liver space-occupying lesions.Malignant lesions show high enhancement in the arterial phase,heterogeneous enhancement,"fast in and fast out"and capsule enhancement,and increased Ktrans and Kep and shortened Tpeak.Ktrans value more than 0.28 min-1 can be used as a reference value for the differential diagnosis of benign and malignant liver space-occupying lesions.
Keywords：liver space-occupying lesionsCDT-VIBE imaging techniquedynamic enhanced scanMRI
Publication Date：2025-07-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 827-833 )