Efficacy of MRI radiomics models in preoperative assessment of T2 and T3 staging of rectal cancer is superior to traditional MRI features
SHEN Qianli
ZHANG Jun
XUE Hongyu
LI Junjun
ZHANG Haiqing
Abstract：Objective To investigate the comparative efficacy of T2 and T3 staging of rectal cancer based on conventional MRI signs and imaging histology.Methods A total of 272 patients with pathologically confirmed T2 and T3 stage rectal cancer were enrolled at the Lujiang Branch of the Tongji University Affiliated Oriental Hospital from December 2021 to December 2024,including 104 patients in the T2 stage and 168 patients in the T3 stage.First,we conducted a comparative analysis of the diagnostic efficacy of preoperative assessment for T2 versus T3 staging of rectal cancer based on multiparametric conventional MRI signs;Second,the enrolled patients were randomly divided into a training group(n=190)and a validation group(n=82)in a 7∶3 ratio;Imaging histological features associated with T2 and T3 staging of rectal cancer were extracted from non-lipid-suppressed T2-weighted sequences,diffusion-weighted imaging,and MRI-enhanced scanning images,respectively,to construct a joint imaging histology model;Finally,receiver operating characteristic curves were plotted for the multiparameter-based conventional MRI signs and the imaging histology model.The area under the curve,specificity,and sensitivity of the corresponding models were calculated to compare and analyze the efficacy of preoperative assessment for T2 and T3 staging of rectal cancer based on the two diagnostic modalities.Results Based on the diagnostic efficacy of conventional multiparametric MRI signs,the AUC was 0.905,the specificity and sensitivity were 0.917 and 0.894;while the highest efficacy was observed in the MRI imaging histology-based joint model training group,the AUC was 0.981,The specificity and sensitivity were 0.944 and 0.929,respectively;In the validation group,the AUC was 0.953,The specificity and sensitivity were 0.926 and 0.898,respectively;and the results were well-calibrated and statistically significant(P<0.05).Conclusion The efficacy of the preoperative assessment for T2 and T3 staging of rectal cancer using the MRI histology model is higher than that of traditional MRI signs,making it worthy of further promotion and application in clinical practice.
Keywords：magnetic resonance imagingimaging histologyrectal cancerT2 stageT3 stage
Publication Date：2025-07-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 814-820 )