Structural and functional abnormalities of the nucleus accumbens in depression with Parkinson's disease:MRI analysis
ZHU Minghui
KALIBUNUER·Mahemuti
HAO Lu
Abstract：Concomitant depression is extremely common among the patients with Parkinson's disease and greatly affects the quality of life and prognosis of Parkinson,at the same time,the importance of recognising and diagnosing depression in Parkinson's remains grossly underestimated in clinical practice.Abnormal structural and functional alterations of the nucleus accumbens,as a key component of the limbic system and reward circuits in the brain,are often regarded as a potential physiological mechanism leading to depression and other psychiatric disorders.In this paper,we would not only take the nucleus accumbens as an entry point,but also review from both structural and functional MRI technology aspects,and discusse the significance of abnormalities in the nucleus accumbens of patients of depression with Parkinson's disease,with the aim of helping clinicians better diagnose and pave new perspectives and ideas for future research work.
Keywords：depression of Parkinson's diseasenucleus accumbensstructural MRIfunctional MRI
Publication Date：2025-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 770-775 )