Research value of the model combining ultrasound radiomics and contrast-enhanced ultrasound in predicting prostate cancer in the gray zone
QIN Shuang
JIA Zhiying
WANG Changchun
WANG Yizhen
ZUBAIRE·Yisikandaier
Abstract：Objective To utilize ultrasound radiomics technology combined with clinical indicators and contrast-enhanced ultrasound(CEUS)to construct a combined model,thereby improving the diagnostic accuracy of PCa in the gray zone.Methods The diagnostic accuracy of prostate cancer(PCa)within the prostate-specific antigen gray zone(4-10 ng/mL)is relatively low,and traditional methods struggle to effectively differentiate between benign and malignant lesions.This study aims to utilize ultrasound radiomics technology combined with clinical indicators and contrast-enhanced ultrasound(CEUS)to construct a combined model,thereby improving the diagnostic accuracy of PCa in the gray zone.Results Among the 137 patients,55 were diagnosed with prostate cancer and 82 had benign lesions.Multivariate logistic regression analysis showed that free prostate-specific antigen and peak intensity were independent predictors of PCa in the gray zone(P<0.05).The combined model achieved AUC values of 0.965 and 0.893 in the training and validation sets,respectively,significantly outperforming the single models.The DCA curve indicated that the combined model had a higher net benefit at low-risk thresholds,and the calibration curve further confirmed its accuracy.Conclusion The combined model constructed using ultrasound radiomics,clinical indicators,and CEUS significantly improves the diagnostic accuracy of PCa in the gray zone,providing an effective auxiliary diagnostic tool for clinical practice.
Keywords：prostate cancergray zoneradiomicscontrast-enhanced ultrasound
Publication Date：2025-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 742-747 )