Prognostic evaluation of pulmonary hypertension patients:based on two dimensional and three dimensional echocardiography

ZHANG Jun; WANG Dan; WANG Zhifen; XUE Jiping; XUE Menghua; ZHANG Yong; GUO Rongrong

doi:10.12122/j.issn.1674-4500.2025.06.12

Abstract：Objective To measure parameters related to right heart function using echocardiography,analyze the right heart function of patients with pulmonary hypertension(PH),and explore independent predictive factors for major cardiovascular adverse events(MACE)in PH patients.Methods A retrospective analysis was conducted on 71 patients with pulmonary hypertension who underwent examination in our hospital.All study subjects underwent two-dimensional and three-dimensional echocardiography,and right heart function parameters were recorded.The endpoint of follow-up is the occurrence of MACE.Independent sample t-test was used to compare right heart function parameters between the MACE group and the non MACE group.Cox proportional hazards regression model was used to analyze the independent predictive factors of MACE,and the optimal cutoff value was obtained based on the ROC curve to plot the Kaplan Meier survival curve.Results Compared with the non MACE group,patients in the MACE group showed an increase in PASP,RVEDVI,and RVESVI,while RVEF,ePAC,TAPSE,TAPSE/PASP,and RVFAC all decreased with statistical significance(P<0.05).Cox analysis showed that TAPSE/PASP and ePAC were independent predictive factors for MACE in PH patients.The Kaplan-Meier survival analysis results showed that the incidence of MACE increased when TAPSE/PASP<0.199 mm/mmHg and ePAC<0.138 cm/mmHg(P<0.05).Conclusion The parameters of right heart function in PH patients with MACE are already poor,while TAPSE/PASP and ePAC can independently predict the occurrence of MACE in PH patients.These indicators can help doctors better assess the patient's condition and prognosis.