Effects of contrast media with different iodine concentrations on image quality and radiation dose of coronary CT angiography

WANG Jingjing; YAO Qiandong; LIU Kun; ZHANG Xiaoyun

doi:10.12122/j.issn.1674-4500.2025.06.11

Abstract：Objective To analyze the effects of contrast media with different iodine concentrations on image quality and radiation dose of coronary computed tomography angiography(CCTA).Methods The data of 144 patients with coronary heart disease who were admitted to the Sichuan Science City Hospital from January 2020 to January 2024 were retrospectively analyzed.All patients underwent dual-source CCTA after admission,and the fixed iodine flow rate was controlled within the same weight range.The patients were divided into group A(n=48),group B(n=48)and group C(n=48)according to different iodine concentrations in contrast media.The iodine concentrations of contrast media used in group A,B and C were 270 mgI/mL,320 mgI/mL,350 mgI/mL,respectively.The subjective image quality,CT values of the aortic root,right coronary artery and proximal left anterior descending artery,image noise,signal-to-noise ratios(SNRs)and radiation doses under contrast media with different iodine concentrations were compared.Results There were no statistically significant differences among the three groups in terms of the distribution of excellent,good and moderate quality of subjective coronary artery display,CT values of the aortic root,right coronary artery and left anterior descending artery,SD value,SNR,CTDI,DLP,ED(P>0.05).Conclusion Under a fixed iodine flow rate,there is no significant difference in image quality and radiation dose of CCTA using contrast media with different iodine concentrations(270,320,350 mgI/mL).For patients without obesity or severe renal dysfunction prioritize,contrast media with low iodine concentration is recommended to reduce the risk of nephrotoxicity.