99m Tc-EC renal dynamic imaging combined with Um-Alb and Uβ2-MG can effectively diagnose renal involvement in primary Sjögren's syndrome
CUI Can
WEN Qingxiang
MENG Yuan
TIAN Lei
LU Suyan
GU Wen
SHI Jin
Abstract：Objective To explore the value of renal dynamic imaging combined with urinary microalbumin(Um-Alb)and urinary β2-microglobulin(Uβ2-MG)in the diagnosis of renal involvement in primary Sjögren's syndrome(pSS).Methods A retrospective analysis of 52 pSS patients attending our hospital from January 2019 to December 2023 included 33 patients in impaired renal function group and 19 in unimpaired renal function group.The renal function curve parameters,ERPF,Um-Alb,Uβ2-MG were collected and compared between the two groups,the diagnostic efficacy of ERPF,Um-Alb,Uβ2-MG and the three combination on pSS renal impairment was compared,and the combined model of the best diagnostic efficacy was constructed and visualized with the Nomogram.Results Between the two groups,time to peak wasn't prolonged,while pSS duration,half time of excretion and 20 min residual rate increased,ERPF was lower,Um-Alb and Uβ2-MG were higher than unimpaired renal function group,and the difference was statistically(P<0.05).ERPF,Um-Alb and Uβ2-MG had higher diagnostic efficacy of pSS renal damage,with AUC of 0.813,0.859 and 0.850 respectively and combined AUC of 0.992.Conclusion Renal dynamic imaging,ERPF combined with Um-Alb and Uβ2-MG can effectively diagnose pSS renal impairment,clinicians can predict the risk of pSS renal impairment and intervene early according to nomogram model.
Keywords：primary Sjögren's syndromerenal dynamic imagingUm-AlbUβ2-MGdiagnostic value
Publication Date：2025-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 678-683 )