Advances in the application of peptide self-assembly technology in tumor imaging and therapy
JIANG Juntao
WU Yujing
WU Hao
XIE Minhao
Abstract：Peptide self-assembling materials,with their excellent biocompatibility,controllability,and ease of synthesis,have shown great potential in tumor diagnosis and treatment.These materials are capable of spontaneously forming a variety of nanostructures through non-covalent interactions,especially under the guidance of enzyme-instructed self-assembly strategy.In this way,they can achieve in situ self-assembly within tumor tissues,leading to precise targeting and formation of diverse nanostructures.This review focuses on the mechanisms of peptide self-assembly,the enzyme-instructed self-assembly strategy,and their applications in tumor imaging and treatment,including fluorescence imaging,positron emission tomography imaging,and photoacoustic imaging.It also explores the applications of peptide self-assembly in directly inducing cancer cell apoptosis,acting as a carrier for anticancer drug delivery,and in tumor immunotherapy.The review aims to sort out the core advantages and key challenges of peptide self-assembly technology,such as targeting precision,in vivo stability,and clinical translation bottlenecks.It then looks ahead to future development directions,including multifunctional integration design and studies on the universality of various tumors,providing theoretical support and technical references for the development of more efficient and safer tumor imaging and therapeutic approaches.
Keywords：peptide self-assemblytumor imagingtumor therapynanomaterialsenzyme-instructed self-assembly
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 639-645 )