Application progress of amide proton transfer-weighted imaging and artificial intelligence integration in breast cancer diagnosis
HOU Lin
LIN Tuanyu
CHEN Tiaoxuan
HUANG Haijian
HUANG Weipeng
Abstract：Amide proton transfer-weighted(APTw)imaging,a unique chemical exchange saturation transfer imaging technique,indirectly quantifies the amide proton content in mobile proteins and peptides and pH changes in tissues by detecting the attenuation of free water signals.This provides insights into tissue metabolism,offering rich molecular-level information for the diagnosis and treatment monitoring of breast cancer.In recent years,the integration of APTw imaging with AI has gained attention in breast cancer diagnosis.This review focuses on the applications of APTw imaging combined with AI in differentiating benign and malignant breast lesions,histological grading,analyzing correlations with biomarkers,and evaluating the efficacy of neoadjuvant chemotherapy.It also discusses the challenges and limitations of this technology in practical applications.
Keywords：amide proton transfer imagingartificial intelligencechemical exchange saturation transfermagnetic resonance imagingbreast cancer
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 633-638 )