Research progress of multimodal magnetic resonance in the diagnosis and early intervention of vascular dementia
WANG Jiong
ZHANG Xuezhu
Abstract：Vascular dementia(VaD)is the second most common type of dementia,characterized primarily by impairments in attention,information processing,and executive function.Accurate differential diagnosis and early intervention remain challenging.MRI with its non-invasive and reproducible features,plays a crucial role in the diagnosis and monitoring of VaD.Structural MRI can identify white matter hyperintensities,gray matter atrophy,ventricular enlargement,and perivascular space changes.Resting-state functional MRI reveals alterations in local brain activity and functional connectivity in VaD patients.Diffusion tensor imaging quantitatively assesses white matter tract abnormalities,while arterial spin labeling enables non-invasive measurement of cerebral perfusion.Additionally,magnetic resonance spectroscopy detects concentrations of brain metabolites.The integration of multimodal MRI analyses further enhances the diagnostic and monitoring potential of MRI for VaD.This review summarizes recent advancements in multimodal MRI applications for the diagnosis of VaD,providing new strategies for early diagnosis,differential diagnosis,disease monitoring,and intervention.
Keywords：vascular dementiamultimodal magnetic resonance imagingdiagnostic biomarkers
Publication Date：2025-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 516-522 )