Diagnostic value of 18 F-FDG PET/CT based on elevated CA125 levels for peritoneal metastasis after ovarian cancer surgery
MIAO Chunyan
LIU Dapai
GAO Fu
YU Chengcheng
MANFEIDA·Maimaiti
PU Wutao
XIA Luhua
Abstract：Objective To compare the diagnostic value of 18F-FDG PET/CT versus conventional imaging methods in patients with postoperative peritoneal metastasis of ovarian cancer based on elevated CA125 levels.Methods This study retrospectively analyzed 87 postoperative patients diagnosed with ovarian cancer at the Affiliated Hospital of Xinjiang Medical University from January 2022 to December 2023.The diagnostic performance of four imaging modalities were investigated:18F-FDG PET/CT,transabdominal ultrasound(TAUS),transvaginal ultrasound(TVUS),contrast-enhanced computed tomography(CECT)or MRI,in detecting peritoneal metastasis in patients with elevated postoperative CA125 levels exceeding 35 U/mL.The parameters compared include sensitivity,specificity,accuracy,positive predictive value,and negative predictive value for each diagnostic method in the context of postoperative peritoneal metastasis in ovarian cancer patients.Results The sensitivities of 18F-FDG PET/CT,TAUS,TVUS,CECT or MRI for diagnosing postoperative peritoneal metastasis in ovarian cancer patients were 96.67%,37.70%,56.67%,79.37%,respectively;specificities were 85.19%,88.46%,92.59%,54.17%,respectively;accuracies were 93.10%,52.87%,67.82%,72.41%,respectively;positive predictive values were 93.54%,88.46%,94.44%,81.97%,respectively;negative predictive values were 92.00%,37.70%,49.02%,50.00%,respectively.Conclusion The accuracy of 18F-FDG PET/CT in diagnosing peritoneal metastasis or recurrence in patients with elevated CA125 levels following ovarian cancer surgery is high,enabling the early detection of peritoneal metastatic lesions.
Keywords：18F-FDG PET/CTconventional imaging methodsCA125ovarian cancerperitoneal metastasis
Publication Date：2025-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 446-452 )