Differences in Hub nodes and modularity of PET metabolic brain network in diffuse large B-cell lymphoma patients pre-and post-chemotherapy
YANG Fan
XIAO Jingke
PENG Daiyun
FU Jingyu
LIU Jiangyan
Abstract：Objective To construct metabolic brain networks in patients with diffuse large B-cell lymphoma(DLBCL)before and after chemotherapy using 18F-FDG PET imaging,and investigate the effect of the disease and R-CHOP chemotherapy regimen on brain function by analyzing differences in hub nodes and modularity.Methods A total of 51 DLBCL patients who underwent whole-body 18F-FDG PET scans before and after chemotherapy at the Nuclear Medicine Department of the Second Hospital of Lanzhou University from June 2021 to July 2024 were included retrospectively,along with 30 age-and sex-matched healthy controls.Inter-regional brain correlations were calculated using the Pearson correlation coefficient to construct the metabolic brain network.Graph theory-based analysis and 1000 permutation tests were subsequently employed to compare the differences in global metrics,Hub nodes,and modularity between DLBCL patients and healthy controls.Results Within the sparsity range of 0.1 to 0.5,DLBCL patients exhibited significant differences in the number and distribution of Hub nodes compared to healthy controls(P<0.05),while maintaining small-world properties(Sigma>1.1).Regarding modularity,alterations in node module assignments were noted in the metabolic brain networks of DLBCL patients at baseline,and the modular structure underwent significant reorganization following chemotherapy.Nevertheless,no significant difference in modularity(Q value)was found when compared to the control group(P>0.05).Conclusion The disease,coupled with R-CHOP chemotherapy regimen,disrupts Hub nodes and modularity of metabolic brain network in DLBCL patients,affecting brain function.
Keywords：diffuse large B-cell lymphomapositron emission tomographymetabolic networkmodularity
Publication Date：2025-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 397-404 )