Septal/honeycomb enhancement,apparent diffusion coefficient value and vascular invasion can effectively distinguish focal chronic inflammatory lesions from cholangiocarcinoma in the liver
LIU Lian
HOU Qin
XIONG Jian
Abstract：Objective To compare the MRI and clinical features of focal chronic inflammatory hepatic lesions(FCIHL)with intrahepatic cholangiocarcinoma(ICC),and improve the accuracy of diagnosis.Methods A retrospective analysis was performed on 14 histologically confirmed cases of FCIHL and 27 histologically confirmed cases of ICC,from April 2019 to October 2023.All patients underwent upper abdominal MRI,including plain scan,enhanced scan,and diffusion-weighted imaging(DWI).Additionally,15 patients underwent Gd-BOPTA MRI.Two radiologists independently analyzed and summarized the clinical and imaging characteristics of both groups,with a third radiologist assessing any discrepancies in measurements.Results Compared to the ICC group,the FCIHL case exhibited higher apparent diffusion coefficient(ADC)values(P<0.05),a higher rate of septal/honeycomb enhancement(P<0.05),and a lower rate of vascular invasion(P<0.05).However,no significant differences were observed between the two groups in lesion shape,margin,maximum diameter,progressive enhancement,local liver atrophy or capsule shrinkage,abnormal perfusion around the lesion,or distal bile duct dilatation(P>0.05).The diagnostic areas under the curve(AUC)for vascular invasion,septal/honeycomb enhancement,and ADC value in differentiating FCIHL from ICC were 0.725,0.660,and 0.827,respectively.There were not statistically significant difference in differentiating FCIHL from ICC with these three signs(P>0.05).Conclusion ADC value,vascular invasion,and septal/honeycomb enhancement are valuable in differentiating FCIHL from ICC.A comprehensive and integrated analysis of these indicators can significantly enhance the accuracy and reliability of differential diagnosis between FCIHL and ICC.
Keywords：liverfocalchronic inflammationintrahepatic cholangiocarcinomaapparent diffusion coefficientvascular invasionseparation/honeycomb strengtheningefficiency
Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 353-359 )