11 C-CFT PET/CT imaging combined with serum LAG-3 and α-SYN has high diagnostic value for Parkinson's disease
XUE Jingting
WANG Tao
CHANG Peiye
Abstract：Objective To explore a potential diagnostic marker for Parkinson's disease(PD)through the combination of 11C-CFT PET/CT imaging and serum lymphocyte activation gene-3(LAG-3)and α-synuclein(α-SYN).Methods Patients with PD who visited the Affiliated Hospital of Inner Mongolia Medical University were recruited as the case group(n=39)from September 2019 to September 2024.Additionally,healthy individuals matched by gender and age were selected as the control group(n=50).Serum LAG-3 and α-SYN concentrations were collected and measured by a quantitative ELISA for patients with PD and age-and sex-matched controls.11C-CFT PET/CT imaging of the subjects was conducted.The relationship between LAG-3,α-SYN,and 11C-CFT PET/CT in Parkinson's patients and controls were assessed via logistic regression.Results According to the ROC curve analysis,the area under the curve of serum LAG-3 in differentiating patients with PD from controls was 0.894 and the cutoff value was 2.024 ng/mL.Sensitivity and specificity were 74.4%and 88.0%,respectively.The area under the curve of serum α-SYN in differentiating patients with PD from controls was 0.844 and the cutoff value was 9.431 ng/mL.Sensitivity and specificity on this receiver operating characteristic curve were 87.2%and 70.0%,respectively.The area under the curve of 11C-CFT PET/CT imaging in differentiating patients with PD from controls was 0.787 and the cutoff value was 1.500.Sensitivity and specificity on this receiver operating characteristic curve were 90.9%and 57.1%,respectively.The area under the curve of the combination of 11C-CFT PET/CT imaging,LAG-3 and α-SYN in differentiating patients with PD from controls was 0.964.Sensitivity and specificity on this receiver operating characteristic curve were 91.3%and 88.2%,respectively.Conclusion Serum LAG-3 and α-SYN concentrations and 11C-CFT PET/CT brain imaging can provide specific and valuable diagnostic information of PD.And the combination of 11C-CFT PET/CT imaging and serum LAG-3 and α-SYN can provide more valuable diagnostic information of PD than individual markers.
Keywords：Parkinson's diseasePET/CT brain imaginglymphocyte activation gene-3α-synuclein
Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 272-277 )