Prenatal prognosis of fetuses with transposition of the great arteries
REN Jie
YANG Dongmei
HUANG Xiangyang
ZHANG Chaoxue
WANG Chunlin
HE Xiaoyan
Abstract：Objective To assess the postnatal outcomes of fetuses diagnosed with large artery dysfunction but ultimately without developing coarctation of the aorta(CoA).Methods A total of 275 cases of prenatal diagnosis of aorto-pulmonary imbalance from January 2019 to March 2023 were extracted from two fetal prenatal ultrasound diagnostic centers of Anhui Provincial Hospital and the First Affiliated Hospital of Anhui Medical University.According to the postpartum follow-up,93 cases(34%)were diagnosed with CoA as the CoA group.The non-CoA group included 182 patients(66%)without CoA.Another 149 cases of normal pregnancy were selected as the normal group.The prenatal data,postpartum follow-up and fetal survival curves of the three groups were analyzed to explore the possible influencing factors of postpartum outcomes.Results In the non-CoA group,after eliminating the fetuses with combined intracardiac or extracardiac malformations,the prognosis of fetuses with simple aortic disproportion was favorable,and there was no statistically significant difference in the long-term survival rate compared with normal fetuses(P>0.05).The same was true for the CoA group compared with the non-CoA group(P>0.05),with better long-term survival.The combination of intracardiac and extracardiac malformations was an influencing factor for the poor postnatal prognosis of fetuses with aortic disproportion.Compared with the normal group,infants with bicuspid aortic valve had a smaller aortic annulus and a faster blood flow velocity at the aortic valve orifice,and the differences were statistically significant(P<0.05).Conclusion The prognosis of fetuses prenatally diagnosed with large artery disorders is closely related to the combined intracardiac and extracardiac malformations.The prognosis of fetuses with isolated aorta-pulmonary incoordination is good.Long-term follow-up is recommended for infants with congenital bicuspid aortic valves.
Keywords：fetal echocardiographyaortic disproportioncoarctation of the aortaprenatal diagnosis
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 180-185 )