18 F-FDG PET/CT combined with serum RNA binding motif protein 38 has predictive value in the diagnosis of postoperative recurrence/metastasis of colorectal cancer
BO Xiangkun
ZHU Rixiang
CHEN Jin
CHEN Saisai
Abstract：Objective To explore diagnostic value of 18F-FDG PET/CT combined with serum RNA binding motif protein 38(RBM38)in postoperative recurrence/metastasis of colorectal cancer.Methods A total of 120 patients with colorectal cancer admitted to Hai'an People's Hospital from January 2021 to August 2023 were enrolled.According to presence or absence of postoperative recurrence/metastasis by pathological examination,patients were divided into occurrence group(n=48)and non-occurrence group(n=72).All patients underwent 18F-FDG PET/CT examination,18F-FDG PET/CT parameters[maximum standardized uptake value(SUVmax),metabolic tumor volume(MTV),total lesion glycolysis(TLG)]and level of serum RBM38 were compared between the two groups.The correlation between serum RBM38 and SUVmax,MTV,TLG was analyzed by Pearson analysis.The predictive value of RBM38,SUVmax,MTV,TLG and combined detection in postoperative recurrence/metastasis of colorectal cancer was analyzed by ROC curves.Results RBM38 level in occurrence group was lower than that in non-occurrence group,while SUVmax,MTV and TLG were higher than those in non-occurrence group(P<0.05).Pearson analysis showed that RBM38 level was negatively correlated with SUVmax,MTV,and TLG(r=-0.600,-0.606,-0566,P<0.05).ROC curves analysis showed that area under the curve,sensitivity and specificity of SUVmax,MTV,TLG,RBM38 and combined detection for predicting postoperative recurrence/metastasis of colorectal cancer were 0.732,0.732,0.706,0.737,0.910;64.58%,66.67%,70.83%,79.17%,89.58%;76.39%,72.22%,65.28%,62.50%,75.00%,respectively(P<0.05).Conclusion 18F-FDG PET/CT combined with serum RBM38 has high predictive value in postoperative recurrence/metastasis of colorectal cancer,which is beneficial to improve the accuracy of clinical prediction and diagnosis.
Keywords：colorectal cancerpostoperative recurrence/metastasis18F-fluorodeoxyglucose positron emission tomography/computed tomographyserum RNA binding motif protein 38
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 104-108 )